If you're no longer interested in a specific conversation, you can choose to unsubscribe from any future notifications.
On GitHub Enterprise, navigate to the main page of the repository.
In the repository's right sidebar, click Issues or Pull requests.
In the sidebar on the right, click Unsubscribe.
Once you unsubscribe from a conversation, you will no longer receive any notifications about the thread. However, if you or a team you're on are @mentioned, you'll once again start receiving notifications.