If you're no longer interested in a specific conversation, you can choose to unsubscribe from any future notifications.

  1. In the upper-right corner of any page, click your profile photo. Sample of an avatar
  2. On your profile page, click the Repositories tab, then click the name of your repository. Repository tab
  3. Click either the Issues tab or the Pull Requests tab for the repository. Issues or Pull Requests tab selection
  4. In the sidebar on the right, click Unsubscribe. Conversation Subscribe button

Once you unsubscribe from a conversation, you will no longer receive any notifications about the thread. However, if you or a team you're on are @mentioned, you'll once again start receiving notifications.